Calorimetric assays showed two different binding events: (i) inhibitor-protein interactions and (ii) toxin oligomerization processes. These hypotheses were also corroborated with dynamic light and small angle X-ray scattering assays. The crystal structure of the MjTX-I/suramin showed a totally different interaction mode compared to other PLA2-like/suramin complexes. Thus, we suggested a novel myotoxic mechanism for MjTX-I that may be inhibited by suramin. These results can further contribute to the search for inhibitors that will efficiently counteract local myonecrosis in order to be used as an adjuvant of conventional serum therapy.
The latter corresponds to the interior of a spherical shell, where the dimensions of the rods are comparable to the radius of curvature of the container: they have to accomodate to fill the available space, leadin...
Utilizando a liberação de saques do fundo do garantia e do PIS-Pasep, governo pretende injetar Ainda mais do R$ 60 bilhões no mercado de modo a tentar alavancar este crescimento do PaÃs
Es una organización superviviente porque se ha adaptado a los cambios y ha mostrado un notable grado de flexibilidad
Two versions of the threshold contact process–ordinary and conservative–are studied on a square lattice. In the first, particles are created on active sites, those having at least two nearest neighbor sites occupied, and are annihilated spontaneously.
Walking along the liquid-vapor coexistence line of daniel dantas mercado livre a pure substance into direction of high pressures and high temperatures, the vapor density increases and the liquid density decreases to the point where the densities of the two phases become equal.
The limited resolution of the SAXS-based model hinders the unequivocal docking of the high resolution structures into the molecular envelope. Thus, we have used structure-based Cys-scanning mutagenesis combined with crosslinking experiments to obtain distance restraints that will help us to elucidate the relative orientation of the FnIII3 and FnIII4 in solution. Our results have implications for the organization of the integrin β4 subunit and for its mechanisms of auto-inhibition and activation.
Structural features of lignin obtained at different alkaline oxidation conditions from sugarcane bagasse
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A system in thermodynamic equilibrium must be stable. This means to say that small perturbations do not remove the system from its equilibrium.
Dielectric materials are Mario de Oliveira insulators characterized by the response to an electric field. An ordinary dielectric, such as water, placed in the presence of an electric field acquires an electric polarization that disappears when the field is removed.
Probabilistic cellular automata are Markovian processes in discrete time described by a set of stochastic variables that reside on the sites of a lattice.
The protein was purified using a combination of ion exchange and size exclusion chromatography rendering here about 30 mg pure protein/l here culture medium. Circular dichroism spectroscopy and small-angle X-ray scattering studies of XcEXLX1 reveal that it is a strongly disordered β-sheet protein. Its low resolution envelope fits nicely the crystallographic structure of the homologous protein EXLX1 from Bacillus subtillis.
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